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Structure-based thresholds of toxicological concern (TTC): Guidance for application to substances present at low levels in the diet

Smoking is one of the leading risks for early death Smoking is responsible for about 8 million premature deaths each year The two regularly updated studies on the global death toll from tobacco use published by the World Health Organization and the Institute for Health Metrics and Evaluation agree that around 8 million people die prematurely yearly

[45] The CDC states that vitamin E acetate is a very strong culprit of concern in VAPI, having been found in 29 out of 29 lung biopsies tested from ten different states, [29] but evidence is not yet sufficient to rule out contribution of other chemicals of concern to VAPI

And I think that element of it also really speaks to the Bay Area culture